Functions Of The Immune System Organs

Functions Of The Immune System Organs – 4. Distinguish between non-specific and specific immunity. Compare and contrast naturally acquired and artificially acquired active and passive immunity.

The human body must always be protected from foreign invasion. It works by using a “layered defense” system that includes the skin and chemical barriers, as well as the innate and adaptive immune system. This subject mainly deals with innate and adaptive immune responses (immunity).

Functions Of The Immune System Organs

Functions Of The Immune System Organs

Immunity is the body’s ability to recognize and destroy specific pathogens, such as bacteria and viruses, as well as parasites, and prevent infectious diseases. The immune system also recognizes some tumor cells. When the immune system is compromised, immunodeficiency diseases may appear. When the immune system is overactive, disorders such as allergies and autoimmune disorders may appear.

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Concept of the immune system to distinguish between “self” (normal body components) and “self” (tissues or foreign substances). In some cases, this mechanism goes wrong and the body destroys its own cells.

Functions Of The Immune System Organs

The body’s immune system includes the bone marrow, lymphoid organs, and the mononuclear phagocyte system (also called the reticuloendothelial system). The main functions of the immune system include protection, homeostasis and surveillance. Box 24-1 describes these functions. Figure 1-24 shows many of the organs and tissues involved in the immune system.

Bone marrow cells can develop into three types of blood cells: erythrocytes (red blood cells), leukocytes (white blood cells [WBCs]), or platelets (platelets). WBCs protect the body from disease organisms, toxins and irritants. The two types of WBC are granular (neutrophils, basophils, and eosinophils) and granular (monocytes and lymphocytes). Lymphocytes are found in the blood, lymph tissues and lymph tissues such as lymph nodes and tonsils. They create immune cells and their precursors. This topic is about lymphocytes.

Functions Of The Immune System Organs

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• Lymphocytes are the “keystone” of the immune system; Only they can detect foreign substances in the body.

• Differentiation of lymphocytes into specialized lymphocytes called B cells (B lymphocytes) and T cells (T lymphocytes) must occur before recognition of foreign invaders begins. T lymphocytes help protect against viral infections and can identify and destroy certain cancer cells. B lymphocytes develop into antibody-producing cells (plasma cells).

Functions Of The Immune System Organs

Basic Concepts Lymphocytes derived from the bone marrow and lymph tissues have the ability to differentiate into specialized cells called B cells and T cells. B cells provide humoral immunity by responding to the presence of antigens to produce antibodies. (The term antigen is short for “antibody generator”) Antibodies target antigens for destruction.

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Proliferating T cells directed by thymus hormones attack infected cells and provide cell-mediated (cell-mediated) immunity.

Functions Of The Immune System Organs

Stem cells in the bone marrow are responsible for both the production and maturation of B lymphocytes. When they mature, B cells can make antibodies. Exposure to antigen in the blood causes B cells to expand and multiply rapidly, producing colonies, and B cells do not respond to all pathogens. Most of the clones develop into plasma cells, which produce antibodies specific for the circulation. These antibodies provide a form of immunity called humoral (ie humoral body fluid) immunity. In the process of humoral immunity, macrophages (large cells) break down and destroy antigens when they recognize antibodies for destruction.

These clones that do not become plasma cells remain in the body as memory cells. Upon repeated exposure to the antigen, the memory cells are immediately ready to produce antibodies. This “immunological memory” makes a person immune to relapse after an illness in many cases (Cohen & Wood, 2005), but this is not true for all illnesses.

Functions Of The Immune System Organs

Immune And Lymphatic Systems

Background A second exposure to an antigen can cause a faster and more dramatic response than the first because of “immunological memory”. The first exposure causes a later delay because it takes time for the antigen to make antibodies. The antibodies are ready and act quickly upon second exposure. This is an important concept related to allergic reactions.

B lymphocytes are found mainly in lymphoid tissues in a float-like structure. They make up 10%-20% of circulating lymphocytes. There are also fewer B cells in the lymph.

Functions Of The Immune System Organs

Basic Concepts B cells recognize all pathogens without antigen processing. Each B cell recognizes a specific antibody

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An antigen (Ag) is any foreign substance or molecule that enters the body and triggers an immune response (activation of B or T lymphocytes). Most antigens are large protein molecules found on the surface of foreign bodies, RBCs or tissue cells; powder; and in poisons and foods. Some carbohydrates and lipids also act as antigens (Cohen & Wood, 2005).

Functions Of The Immune System Organs

An antibody (Ab) is a protein substance that the body produces in response to an antigen. B lymphocytes are responsible for producing antibodies. All antibodies are found in a fraction of the blood plasma called the gamma-globulin fraction. Antibodies are therefore commonly called gamma globulins or immunoglobulins (Ig) (Cohen & Wood, 2005). The five main groups of immunoglobulins are:

• IgM: stimulates complement activity. This is an antibody produced when exposed to an antigen (for example, after the first tetanus vaccine). IgM is abundant in the blood, but is often absent from organs and tissues and is not transferred across the placenta.

Functions Of The Immune System Organs

Interaction Between Microbiota And Immunity In Health And Disease

• IgG: protects against toxins, viruses and bacteria before birth. . It exists in blood (vascular) and tissues (extravascular). IgG (often called gamma globulin) is the main component of commercial immunoglobulin.

• IgA: protects mucosal surfaces. A major component of secretions such as saliva, tears and bronchial fluids, IgA is transported across the membrane. It is important to avoid entering bacteria through the nose, eyes, lungs and intestines. IgA is found in blood as well as gastrointestinal (GI) secretions and mucus. It is also found in breast milk.

Functions Of The Immune System Organs

• IgE: responsible for immediate allergic reactions, including latex allergy. Although this antibody poses problems in developed countries, it is useful in the fight against parasitic infections such as river blindness in developing countries.

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• IgD: It is believed to act as an antigen receptor. It is present in very small amounts in the blood.

Functions Of The Immune System Organs

Each antigen (foreign invader) stimulates the production of specific antibodies. The body can create about a million antibodies. Antibodies do not destroy antigens, but bind to antigens for destruction by other substances.

Background IgG is the most abundant immunoglobulin found in the blood. Maternal IgG passes through the placenta to the fetus, thus transferring immunity to the fetus during the first months of the baby’s life.

Functions Of The Immune System Organs

Human Digestive System

Nurse latex allergy may be caused by an IgE-mediated reaction. Latex allergy can be caused by skin or mucous membrane contact, or inhalation. Exposed people may have symptoms of urticaria (hives), dermatitis (usually hands), asthma or severe anaphylaxis (allergic shock reaction).

A child with spina bifida (a birth defect of the spine) is at increased risk of latex allergy because the cystic membranes of the kidneys and bladder are often exposed to latex during tests and procedures, such as urinary catheterization. It is recommended that latex-free gloves and other materials be used as much as possible for all children, especially those with these disorders (this will help prevent latex allergies in healthcare settings).

Functions Of The Immune System Organs

Some of the immature stem cells produced in the bone marrow become T cells (thymic lymphocytes) in the thymus gland. T cells make up the remaining 80% to 90% of circulating lymphocytes. While in the thymus, T cells proliferate and become sensitized (capable of binding to certain foreign antigens). T lymphocytes produce immunity called cell-mediated immunity.

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T lymphocytes are normally responsible for fighting cancer cells, viruses and intracellular parasites. They are especially important in dealing with viruses because they kill the host cell and prevent replication. T cells allow the body to distinguish between self and non-self. It usually helps in the fight against foreign pathogens. However, this function can become problematic, for example when T cells cause tissue or organ rejection after transplantation. This is because T cells recognize these tissues as “self” and act to eliminate them. (For most transplant recipients, special anti-rejection drugs must be given to counteract this rejection.)

Functions Of The Immune System Organs

There are several types of T lymphocytes, each with its own function. In order for a T cell to react with a specific antigen, the antigen must first be presented to the T cell on the surface of the macrophage. Macrophages, in combination with T cells, release substances called interleukins that stimulate T cell growth (Cohen & Wood, 2005). Table 24-1 lists the types and related functions of B lymphocytes and T lymphocytes.

One type of T cell is called a helper T cell. There are several types of helper T cells. These cells often lack cytotoxic (cell killing) function. They help regulate the innate and adaptive immune responses. they

Functions Of The Immune System Organs

Lymphatic System Anatomy And Physiology

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