Symptoms Of Overactive Immune System – Allergies have increased over the past few decades in the United States and other Western countries, but are relatively rare in other parts of the world where sanitation is poor.
One theory — called the “hygiene hypothesis” — is that exposure to more bacteria and viruses keeps the immune system so busy, it doesn’t have time for allergies.
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Studies of populations in East and West Germany and of Mexican immigrants to the United States seem to support this. However, asthma rates have begun to decline in many industrialized countries despite cleaner environments.
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Avoidance is the best treatment for any allergy: Don’t eat Snickers bars if you have a peanut allergy. But if you’re allergic to something unavoidable like grass, pollen, or dust, treatments are available to ease symptoms.
• EpiPen injects a pre-measured amount of the hormone epinephrine in the event of a severe allergic reaction. Epinephrine reverses the blood-dilating effects of histamine, reducing swelling that can cause severe breathing and swallowing problems.
• Venom immunotherapy, like allergy shots, desensitizes about 90 percent of patients with insect-sting allergies to the venom.
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Note to Readers: We may earn a commission if you make a purchase through our affiliate links. Lupus is a chronic autoimmune disease in which the body’s immune system becomes overactive and attacks healthy tissue. Because of its complex nature, lupus is sometimes referred to as the “disease of a thousand faces.”
According to the Lupus Foundation of America, people report about 16,000 new cases of lupus each year in the United States, and 1.5 million people in the U.S. may be living with the condition.
There are several types of lupus, including systemic lupus erythematosus (SLE), cutaneous lupus (such as discoid lupus erythematosus [DLE]), drug-induced lupus (DIL), and neonatal lupus.
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SLE is the most common form of lupus, accounting for 70% of lupus cases. This is a systemic condition. This means it can affect many organs and systems throughout the body. For this reason, SLE is called a more severe form of lupus. Symptoms can range from mild to severe.
The condition typically goes through a cycle of flare-ups and remissions. During remission, a person with lupus has no symptoms. During a flare, the disease is active and a person’s symptoms may return or new symptoms may appear.
Some people with SLE may have regular flare-ups. Others may experience them every few years. Still others may experience prolonged activity.
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In DLE, a form of cutaneous lupus, symptoms affect only the skin. DLEs appear as circular lesions, typically on the scalp and face, although they can appear on other parts of the body, such as inside the ears.
The lesions are red and may become thick and scaly. In some cases, the lesions cause scarring and discolouration of the skin. If the scalp is scarred, hair may not grow back in that area.
DLE does not affect internal organs, but about 10% of people with DLE develop SLE, according to the Lupus Foundation of America. However, it is possible that these people already had SLE and that their skin symptoms led to the first DLE diagnosis.
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Subacute cutaneous lupus erythematosus refers to skin lesions that appear on areas of the body exposed to sunlight. These lesions do not cause scarring but may discolor the skin.
DIL is an autoimmune condition caused by certain drugs. Symptoms can be similar to those of SLE, but are often less severe. more than
Symptoms of DIL may appear after months or years of continuous treatment with these drugs. Approximately 5% of people taking hydralazine and 20% of people taking procainamide chronically will develop DIL. Although other drugs can induce DIL, the chances are very low.
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Neonatal lupus is a condition that occurs in babies when their birth parents pass certain antibodies across the placenta during pregnancy.
Antibodies that can cause neonatal lupus are associated with lupus and Sjögren’s disease. Birth parents may have one of these conditions or may have no symptoms, but still pass on these antibodies. If this happens, the child is more likely to develop neonatal lupus
Skin symptoms of neonatal lupus usually disappear after a few weeks. However, some infants may have congenital heart block, where the heart cannot control a normal and rhythmic pumping action. This is a more serious complication and the child may need a pacemaker.
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Most infants born to parents with SLE are completely healthy. However, a person with SLE can talk to a doctor about how their condition may affect their pregnancy.
The immune system is a complex network of organs, tissues and cells. It protects the body by fighting foreign bodies such as viruses, bacteria, fungi and toxins. It also removes dead or damaged cells.
The immune system protects the body by producing Y-shaped proteins called antibodies. These antibodies neutralize the threat or send signals to other cells to eliminate it. Antibodies are produced by specialized white blood cells called B lymphocytes.
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When a person has an autoimmune condition, such as lupus, the immune system cannot distinguish between unwanted substances or antigens and healthy tissue. The body rejects itself as mistakenly strange.
As a result, the immune system directs antibodies against both healthy tissue and antigens. This causes swelling, pain and tissue damage.
Antinuclear antibodies (ANAs) are often present in people with autoimmune conditions such as lupus. They work by targeting the nucleus of the body’s own cells. The nucleus is the part of the cell that contains the genetic material.
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Researchers still don’t fully understand what causes lupus, but they believe it is caused by several factors.
One possible theory relates to cell death, a natural process that occurs when cells are renewed in the body. Research suggests that due to genetic factors, the body of people with lupus does not clear away dead cells properly.
Lupus can develop in response to a variety of factors. It can be hormonal, genetic, environmental or a combination of these factors.
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Hormones are chemicals produced in the body. They control and regulate the activities of certain cells and organs.
Women between the ages of 15 and 44 are nine times more likely to develop lupus than men.
Symptoms and diagnosis are most common between the ages of 15 and 45 years, the reproductive age. However, 20% of cases appear after 50 years.
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This suggests that exposure to estrogen, a sex hormone that women produce more than men, may increase the risk of autoimmune conditions such as lupus.
This is further supported by the fact that many women experience more lupus symptoms before menstruation and during pregnancy, when estrogen levels are high.
Although more research is needed, the presence of certain sex hormones may explain why lupus is so common in older women.
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Although more research is needed, scientists have identified some genes that play a role in the immune system’s response that may contribute to the development of lupus. Evidence suggests that a family member is more likely to develop lupus, and supports the possibility that genetics may be a risk factor.
Twin studies have also shown that if one member of identical twins has lupus, the other has a 24% chance of developing the disease.
Lupus can occur in people with no family history of the disease, but other autoimmune conditions may run in the family.
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People of any background can develop lupus, but African American, Hispanic/Latina, Asian American, Native American, Alaska Native, Native Hawaiian, and other Pacific Islander women are two to three times more likely than white women.
Suggests that for women of color, symptoms begin earlier and are more severe. This research emphasizes the need for increased medical attention, early diagnosis and treatment.
Lupus risk factors include genetic and environmental factors. Genetics may be the reason lupus is more common in certain demographics. However, differences in some outcomes, such as disease progression and mortality, may be due to social factors such as disparities in health care.
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Lupus can occur in people of any age. According to the American College of Rheumatology, 20% of people with lupus develop the condition before age 20. It is rare for lupus to develop before age 5.
Lupus that develops in childhood has more severe symptoms and often affects the kidneys, with 50% of children having kidney symptoms.
Lupus symptoms occur during flare-ups. During flare-ups, people often experience a period of remission, with few or no symptoms.
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Lupus can vary from person to person. Evidence suggests that lupus may be different in men and women. Women show less severe symptoms than men.
A common misconception is that only women can get lupus. Although less common, men can also develop lupus.
If a person has lupus, they are more likely to get an infection because both the disease and
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